September 26, 2025
Last week did not go as planned as the Indiana Hoosiers took the Illini out to the woodshed and applied a beating.
Now the Illini face #21 USC.
How will this game turn out?
It's time to see what the guys think.
| IlliniGuy | Prediction | 25 Season Record |
| IlliniGuy Larry | USC 24-16 | 3-1 |
| IlliniGuy Brad | USC 38-28 | 3-1 |
| IlliniGuy Mike | Illinois 31-28 | 3-1 |
| Kedric Prince | USC 38-24 | 4-0 |
| Matt Stevens | USC30-16 | 4-0 |
| Zain Bando | USC 27-20 | 3-1 |
| Connor Cagley | USC 34-17 | 3-1 |
| Steve Sturm | USC 30-27 | 3-1 |
| Patrick Quinn | USC 31-28 | 3-1 |
| IlliniGuy Chris | USC 42-24 | 3-1 |
| IlliniGuy Karl | Illinois 21-20 | 3-1 |
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