September 2, 2022
The Illini travel to Bloomington, IN to play their second game (and their first on the road) against an Indiana team playing their first game of the season.
Everyone was correct last week. Can that happen again?
Let's see how the IlliniGuys see this week's game:
| IlliniGuy | Prediction | Season Record |
| IlliniGuy Larry | Illinois 31-21 | 1-0 |
| IlliniGuy Brad | Illinois 27-24 | 1-0 |
| IlliniGuy Mike | Illinois 28-14 | 1-0 |
| Kedric Prince | Illinois 28-17 | 1-0 |
| Matt Stevens | Illinois 28-23 | 1-0 |
| Zain Bando | Illinois 34-13 | 1-0 |
| Connor Cagley | Illinois 21-17 | 1-0 |
| Steve Sturm | Illinois 24-21 | 1-0 |
| Patrick Quinn | Illinois 13-10 | 1-0 |
| IlliniGuy Chris | Illinois 34-17 | 1-0 |
| IlliniGuy Karl | Illinois 21-17 | 1-0 |
| Illiniduce (subscriber) | Illinois 24-17 | 1-0 |
| cmore79 (subscriber) | Illinois 20-14 | 1-0 |
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